With over 2.2 billion urban residents and more than half of the world’s largest cities, Asia and the Pacific is undergoing rapid urbanization, with the urban population projected to increase by an additional 1.2 billion by 2050. This accelerated growth is intensifying pressure on land resources, infrastructure, and ecosystems. Expanding urban footprints, declining green spaces, and increasing reliance on private transport are amplifying exposure to climate-related risks, particularly for the region’s approximately 600 million people living in hazard-prone areas with limited access to basic services and infrastructure. Spatial planning plays a crucial role in ensuring urban resilience as current zoning patterns often neglect environmental concerns. There is a need for a paradigm shift towards climate-sensitive spatial planning which incorporates strategic environmental and climate risk assessments. This brief examines Multifunctional Land Use (MLU) planning as a strategy to integrate diverse urban functions such as housing, transportation, water management, green infrastructure, and economic activities, which help cities reduce emissions, improve adaptation capacity, and deliver broader co-benefits. Further, the brief highlights that efficient mixed land use planning requires integrated policy and governance, access to climate finance and improved capacities at the local level.