Loss of biodiversity, climate adaptation needs, and unsustainable urbanization represent multiple crises felt in the Asia-Pacific region. These interconnected challenges threaten natural and built ecosystems and human wellbeing. There is a pressing need for transformative, multi-level actions. This brief examines the potential for nature-based solutions (NbS) to address these crises holistically and provide economic, social, biodiversity, and resilience benefits. To achieve Target 12 of the Convention on Biological Diversity (CBD), this brief recommends strengthening NbS integration in urban planning and policy, encouraging NbS Localization, using blended finance mechanisms, and harnessing scientific and local indigenous knowledge to scale NbS implementation in Asia and the Pacific cities and communities.